Steve Carell as Felonious Gru, the former villain turned Anti-Villain League agent, Margo, Edith, and Agnes' adoptive father, and Lucy's husband.[8]
Carell also voices Dru, Gru's long-lost twin brother and the girls' adoptive uncle.[8][9]
Kristen Wiig as Lucy Wilde, an Anti-Villain League agent, Gru's wife and the girls' adoptive mother.[10]
Trey Parker as Bratt, a supervillain and former child star who grows up to become obsessed with the character he played in the '80s and is bent on world domination.[8]